Pluripotent Stem Cells from Maturing Oocytes
نویسندگان
چکیده
منابع مشابه
Induced Pluripotent Stem Cells: Challenges and Opportunities
Regenerative capacity of mammals is limited and can rarely regenerate a specific organ or tissue fully. Due to these limitations, regenerative medicine seeks efficient and safe cell sources for regeneration of damaged tissues and organs or treatment for incurable diseases. Human embryonic stem cells (HESCs) hold two important properties called self renewal and pluripotency. However, the use of ...
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1.1 Importance of Spermatogonial Stem Cells (SSCs) Spermatogonial stem cells (SSCs) are undifferentiated germ cells that balance self-renewing and differentiating divisions to maintain spermatogenesis throughout adult life. This is a productive stem cell system that produces millions of spermatozoa each day while also maintaining rigorous quality control to safeguard germline integrity. SSCs ar...
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Background: We have recently shown that human embryonic (hESCs) and induced pluripotent stem cells (hiPSCs) can differentiate into advanced spermatogenic cells including round spermatids by in vitro culture (Easley et al., Direct differentiation of human pluripotent stem cells into haploid spermatogenic cells. Cell Reports 2, 440-446 2012) and also, in collaboration, that rhesus spermatogonial ...
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Kidney disease is a growing health issue for modern society,1–3 and there are a number of causes, including prematurity, genetic abnormalities, inflammation, hypertension, and diabetes. Current treatments for ESRD include dialysis and transplantation, but both are expensive, rely on continuous intervention, and are imperfect in their application.4 – 6 Transplantation also suffers from lack of a...
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The direct reprogramming of human somatic cells to induced pluripotent stem cells (iPSCs) offers exciting prospects for disease modelling and regenerative medicine. Several recent reports support the feasibility of generating various blood cell types from iPSCs through in vitro-directed differentiation. However, the derivation of hematopoietic stem cells (HSCs) capable of long-term reconstituti...
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ژورنال
عنوان ژورنال: Cellular Reprogramming
سال: 2013
ISSN: 2152-4971,2152-4998
DOI: 10.1089/cell.2013.0028